Environmentals (temps / humidity)
Nutrients (timing and amount)
And just fine tuning it all to work together is the key. Ever bump in the road in flower is less time the buds are maximizing their potential. As @TheVirginian said, the indoor factors (total control and getting to ‘play god’) normally means a superior product nowadays. But you have to tune things to your grow.
Mixing never seems to effect my plants negatively, but ive never used the trio nor the dozen…. Go from organic to organic lol. But Jacks seems to have alot of fans around here and Ive seen the baseball bats it can put out. FF just causes more questions then anything else around. Not saying it doesnt work, but it has a large window for error…
If the blue planet worked smoothly, run with it. Maybe do a side by side with Jacks. (It wont be purely scientific without clones, and pretty decent setup). But itll give some data.
Also phenotype/genetics comes into play. What strains did you run?